BREAST (23)    AJCC STAGING GROUPS (164.33)

• DESCRIPTION:   NCA
  CODE:   NX
• DESCRIPTION:   Metastasis in clinically apparent internal, etc
  CODE:   N2b
• DESCRIPTION:   Metastasis in 10 or more axillary lymph nodes, etc
  CODE:   N3
• DESCRIPTION:   Metastasis in 10 or more axillary lymph nodes, etc
  CODE:   N3a
• DESCRIPTION:   Metastasis in clinically apparent ipsilateral, etc
  CODE:   N3b
• DESCRIPTION:   Metastasis in ipsilateral supraclavicular
  CODE:   N3c
• DESCRIPTION:   NA
  CODE:   NA
• DESCRIPTION:   No metastasis, negative IHC
  CODE:   N0(i-)
• DESCRIPTION:   No metastasis, positive IHC, no cluster > 0.2 mm
  CODE:   N0(i+)
• DESCRIPTION:   No metastasis, negative molecular findings
  CODE:   N0(mol-)
• DESCRIPTION:   No metastasis, positive molecular findings
  CODE:   N0(mol+)
• DESCRIPTION:   NRN
  CODE:   N0
• DESCRIPTION:   Metastasis in 1 to 3 axillary lymph nodes, etc
  CODE:   N1
• DESCRIPTION:   Micrometastasis
  CODE:   N1mi
• DESCRIPTION:   Metastasis in 1 to 3 axillary lymph nodes
  CODE:   N1a
• DESCRIPTION:   Metastasis in internal mammary nodes etc
  CODE:   N1b
• DESCRIPTION:   Metastasis in 1 to 3 axillary lymph nodes, etc
  CODE:   N1c
• DESCRIPTION:   Metastasis in 4 to 9 axillary lymph nodes, etc
  CODE:   N2
• DESCRIPTION:   Metastasis in 4 to 9 axillary lymph nodes, etc
  CODE:   N2a

Regional Lymph Nodes (N) Pathologic
N0(mol-) No regional lymph node metastasis histologically, negative
           molecular findings (RT-PCR)
N0(mol+) No regional lymph node metastasis histologically, positive
           molecular findings (RT-PCR)
N1       Metastasis in 1 to 3 axillary lymph nodes, and/or in internal
           mammary nodes with microscopic disease detected by sentinel
           lymph node dissection but not clinically apparent 
N1mi     Micrometastasis (greater than 0.2 mm, none greater than 2.0 mm)   
N1a      Metastasis in 1 to 3 axillary lymph nodes
N1b      Metastasis in internal mammary nodes with microscopic disease

           detected by sentinel lymph node dissection but not clinically
           apparent
N1c      Metastasis in 1 to 3 axillary lymph nodes and in internal mammary
           lymph nodes with microscopic disease detected by sentinel lymph
           node dissection but not clinically apparent
N2       Metastasis in 4 to 9 axillary lymph nodes, or in clinically
           apparent internal mammary lymph nodes in the absence of axillary
           lymph node metastasis
N2a      Metastasis in 4 to 9 axillary lymph nodes (at least one tumor
           deposit greater than 2.0 mm)
NX       Regional lymph nodes cannot be assessed (eg, previously removed,
N2b      Metastasis in clinically apparent internal mammary lymph nodes in
           the absence of axillary lymph node metastasis
N3       Metastasis in 10 or more axillary lymph nodes, or in infraclavicular
           lymph nodes, or in clinically apparent ipsilateral internal mammary
           lymph nodes in the presence of 1 or more positive axillary lymph
           nodes; or in more than 3 axillary lymph nodes with clinically
           negative microscopic metastasis in internal mammary lymph nodes; or
           in ipsilateral supraclavicular lymph nodes
N3a      Metastasis in 10 or more axillary lymph nodes (at least one tumor
           deposit greater than 2.0 mm), or metastasis to the infraclavicular
           or not removed for pathologic study)
           lymph nodes
N3b      Metastasis in clinically apparent ipsilateral internal mammary lymph
           nodes in the presence of 1 or more positive axillary lymph nodes;
           or in more than 3 axillary  lymph nodes and in internal mammary
           lymph nodes with microscopic disease detected by sentiel lymph
           node dissection but not clinically apparent
N3c      Metastasis in ipsilateral supraclavicular lymph nodes
N0       No regional lymph node metastasis histologically, no additional
           examination for isolated tumor cells (ITC)
N0(i-)   No regional lymph node metastasis histologically, negative IHC
N0(i+)   No regional lymph node metastasis histologically, positive IHC,
           no IHC cluster greater than 0.2 mm

• NCA
  CODE:   NX
  ACOS CODE:   NX
• Ipsilateral axillary fixed
  CODE:   N2
  ACOS CODE:   N2
• Ipsilateral internal mammary
  CODE:   N3
  ACOS CODE:   N3
• NA
  CODE:   NA
  ACOS CODE:   NA
• NRN
  CODE:   N0
  ACOS CODE:   N0
• Movable ipsilateral axillary lymph node(s)
  CODE:   N1
  ACOS CODE:   N1
• Micrometastasis (< 0.2 cm)
  CODE:   N1a
  ACOS CODE:   N1A
• Any > 0.2 cm
  CODE:   N1b
  ACOS CODE:   N1B
• 1 - 3, any > 0.2/all < 2 cm
  CODE:   N1bi
  ACOS CODE:   N1BI
• 4 or more, any > 0.2/all < 2 cm
  CODE:   N1bii
  ACOS CODE:   N1BII
• Beyond capsule < 2 cm
  CODE:   N1biii
  ACOS CODE:   N1BIII
• 2 cm or more
  CODE:   N1biv
  ACOS CODE:   N1BIV

Regional Lymph Nodes (N)
             and all less than 2 cm in greatest dimension
    N1bii  Metastasis to 4 or more lymph nodes, any more than 0.2 cm
             and all less than 2 cm in greatest dimension
    N1biii Extension of tumor beyond the capsule of a lymph node
             metastasis less than 2 cm in greatest dimension
    N1biv  Metastasis to a lymph node 2 cm or more in greatest dimension
N2  Metastasis to ipsilateral axillary lymph nodes that are fixed to one
      another or to other structures
N3  Metastasis to ipsilateral internal mammary lymph node(s)

NX  Regional lymph nodes cannot be assessed (e.g., previously
      removed, or not removed for pathologic study)
N0  No regional lymph node metastasis
N1  Metastasis to movable ipsilateral axillary lymph node(s)
    N1a    Only micrometastasis (none larger than 0.2 cm)
    N1b    Metastasis to lymph node(s), any larger than 0.2 cm
    N1bi   Metastasis is 1 to 3 lymph nodes, any more than 0.2 cm