| COMMENTS |
Transmissible spongiform encephalopathies (TSEs or prion diseases) are a rare gr
oup of invariably fatal neurodegenerative disorders that affect humans and other
mammals. TSEs are protein misfolding diseases that involve the accumulation of
an abnormally aggregated form of the normal host prion protein (PrP). They are u
nique among protein misfolding disorders in that they are transmissible and have
different strains of infectious agents that are associated with unique phenotyp
es in vivo. https://pubmed.ncbi.nlm.nih.gov/19157856/#:~:text=Abstract,host%20p
rion%20protein%20(PrP).
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