| COMMENTS |
Multigene analysis for inherited thrombocytopenia (IT), a group of hereditary di
sorders characterized by a reduced platelet count, abnormal platelet function, f
ollowed by impaired haemostasis. Over 40 genes have been known to cause differen
t forms of inherited thrombocytopenia. However, the identification of the underl
ying causative gene in a patient is challenging given the high degree of heterog
eneity. Testing does provide insight into the various clinical presentations and
prognosis, where some defects can lead to hematological malignancies.[PMID: 312
75945]
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