EYE, RETINA (67692)    ICDO TOPOGRAPHY (164)

Primary Tumor (T)
T3a Tumor(s) involve(s) more than 50% of the retina
      and/or tumor cells in the vitreous
T3b Tumor(s) involve(s) optic disc
T3c Tumor(s) involve(s) anterior chamber and/or uvea
T4  Tumor with extra-ocular invasion
T4a Tumor invades retrobulbar optic nerve
T4b Extra-ocular extension other than invasion of optic nerve

Note: The following suffixes may be added to the appropriate T categories:
"m" indicates multiple tumors (e.g. T2m2); "f" indicates cases with a known

family history; and "d" indicates diffuse retinal involvement without the
formation of discrete masses.
TX  Primary tumor cannot be assessed
T0  No evidence of primary tumor
T1  Tumor(s) limited to 25% or less of the retina
T2  Tumor(s) involve(s) more than 25% but not more
      than 50% of the retina
T3  Tumor(s) involve(s) more than 50% of the retina and/or
      invade(s) beyond the retina but remain(s) intra-ocular

Regional Lymph Nodes (N)

NX  Regional lymph nodes cannot be assessed
N0  No regional lymph node metastasis
N1  Regional lymph node metastasis

• DESCRIPTION:   CBA
  CODE:   TX
• DESCRIPTION:   Invasion of optic nerve and/or optic coats
  CODE:   T3
• DESCRIPTION:   Extraocular tumor
  CODE:   T4
• DESCRIPTION:   NA
  CODE:   NA
• DESCRIPTION:   NET
  CODE:   T0
• DESCRIPTION:   Confined to the retina
  CODE:   T1
• DESCRIPTION:   < or = 3 mm in height/< 1 DD to optic nerve/fovea
  CODE:   T1a
• DESCRIPTION:   Confined to retina regardless of location or size
  CODE:   T1b
• DESCRIPTION:   Contiguous spread to adjacent tissues or spaces
  CODE:   T2
• DESCRIPTION:   Minimal spread to vitreous and/or subretinal space
  CODE:   T2a
• DESCRIPTION:   Massive spread to vitreous and/or subretinal space
  CODE:   T2b
• DESCRIPTION:   Unsalvageable introocular disease
  CODE:   T2c

Primary Tumor (T)
       nerve or fovea
T1b  All other eyes in which the tumor(s) are confined to the retina
       regardless of location or size (up to half the volume of the eye).
       No vitreous seeding.  No retinal detachment or subretinal fluid >5 mm
       from the base of the tumor.
T2   Tumor with contiguous spread to adjacent tissues or spaces (vitreous or
       subretinal space).
T2a  Minimal spread to vitreous and/or subretinal space
T2b  Massive spread to vitreous and/or subretinal space
T2c  Unsalvageable intraocular disease

T3   Invasion of optic nerve and/or optic coats
T4   Extraocular tumor
TX   Primary tumor cannot be assessed
T0   No evidence of primary tumor
T1   Tumor confined to the retina (no vitreous seeding or significant retinal
       detachment).  No retinal detachment or subretinal fluid >5 mm from the
       base of the tumor
T1a  Any eye in which the largest tumor is less than or equal to  3 mm in
       height and no tumor is located closer than 1 DD (1.5 mm) to the optic

• DESCRIPTION:   NCA
  CODE:   NX
• DESCRIPTION:   No regional lymph node involvement
  CODE:   N0
• DESCRIPTION:   Regional lymph node involvement
  CODE:   N1
• DESCRIPTION:   NA
  CODE:   NA

Regional Lymph Nodes (N)

NX  Regional lymph nodes cannot be assessed
N0  No regional lymph node involvement
N1  Regional lymph node involvement (preauricular,
      submandibular, or cervical)

• DESCRIPTION:   Distant metastasis cannot be assessed
  CODE:   Mx
• DESCRIPTION:   No distant metastasis
  CODE:   M0
• DESCRIPTION:   Distant metastasis
  CODE:   M1
• DESCRIPTION:   NA
  CODE:   NA

Distant Metastasis (M)

MX  Distant metastasis cannot be assessed
M0  No distant metastasis
M1  Distant metastasis

• T-CODE:   X
• T-CODE:   3A
• T-CODE:   3B
• T-CODE:   4A
• T-CODE:   4B
• T-CODE:   4C
• T-CODE:   4D
• T-CODE:   1A
• T-CODE:   1B
• T-CODE:   1C
• T-CODE:   2A
• T-CODE:   2B

Primary Tumor (T)
      located closer than 1.5 mm to the optic nerve or fovea. No retinal
      detachment or subretinal fluid beyond 5 mm from the base of the
      tumor
T1c  At least one tumor is greater than 3 mm in largest dimension or
      located closer than 1.5 mm to the optic nerve or fovea. With retinal
      detachment or subretinal fluid beyond 5 mm from the base of the
      tumor
T2   Tumors no more than 2/3 the volume of the eye with vitreous or
      subretinal seeding. Can have retinal detachment.
T2a  Focal vitreous and/or subretinal seeding of fine aggregates of tumor 
 
      cells is present, but no large clumps or "snowballs  of tumor cells
T2b  Massive vitreous and/or subretinal seeding is present, defined as
      diffuse clumps or "snowballs  of tumor cells
T3   Severe intraocular disease
T3a  Tumor fills more than 2/3 of the eye.
T3b  One or more complications present, which may include tumor-associated
      neovascular or angle closure glaucoma, tumor extension into the
      anterior segment, hyphema, vitreous hemorrhage, or orbital
      cellulitis
T4   Extraocular disease detected by imaging studies
TX   Primary tumor cannot be assessed
T4a  Invasion of optic nerve
T4b  Invasion into the orbit.
T4c  Intracranial extension not past chiasm
T4d  Intracranial extension past chiasm
T0   No evidence of primary tumor
T1   Tumors no more than 2/3 the volume of the eye with no vitreous or 
      subretinal seeding
T1a  No tumor in either eye is greater than 3 mm in largest dimension or 
      located closer than 1.5 mm to the optic nerve or fovea
T1b  At least one tumor is greater than 3 mm in largest dimension or

• N-CODE:   X

Regional Lymph Nodes (N)
 
NX  Regional lymph nodes cannot be assessed
N0  No regional lymph node involvement
N1  Regional lymph node involvement (preauricular, cervical,
     submandibular)
N2  Distant lymph node involvement

• M-CODE:   1A
• M-CODE:   1B
• M-CODE:   1C
• M-CODE:   1D
• M-CODE:   1E

Distant Metastasis (M)
 
M0   No distant metastasis
M1   Systemic metastasis
M1a  Single lesion to sites other than CNS
M1b  Multiple lesions to sites other than CNS
M1c  Prechiasmatic CNS lesion(s)
M1d  Postchiasmatic CNS lesion(s)
M1e  Leptomeningeal and/or CSF involvement

• RETINA

• CBA
  CODE:   TX
  ACOS CODE:   TX
• Retrobulbar optic nerve
  CODE:   T4a
  ACOS CODE:   T4A
• Extra-ocular extension
  CODE:   T4b
  ACOS CODE:   T4B
• NA
  CODE:   NA
  ACOS CODE:   NA
• NET
  CODE:   T0
  ACOS CODE:   T0
• Limited to 25% or less of retina
  CODE:   T1
  ACOS CODE:   T1
• > 25% but not > 50%
  CODE:   T2
  ACOS CODE:   T2
• > 50%/beyond retina but intra-ocular
  CODE:   T3
  ACOS CODE:   T3
• > 50%/in vitreous
  CODE:   T3a
  ACOS CODE:   T3A
• Optic disc
  CODE:   T3b
  ACOS CODE:   T3B
• Anterior chamber/uvea
  CODE:   T3c
  ACOS CODE:   T3C
• Extra-ocular invasion
  CODE:   T4
  ACOS CODE:   T4

• NCA
  CODE:   NX
  ACOS CODE:   NX
• NRN
  CODE:   N0
  ACOS CODE:   N0
• Regional lymph node metastasis
  CODE:   N1
  ACOS CODE:   N1
• NA
  CODE:   NA
  ACOS CODE:   NA